N I N E T

Non-Invasive Neurostimulation Therapies

NINET – Non-Invasive Neurostimulation Therapies

Principal Investigator: Dr. Lakshmi Yatham, Department of Psychiatry, UBC

The UBC Mood Disorders Centre at UBC Hospital is looking for participants diagnosed with bipolar I who are currently depressed to participate in a double-blind study. The purpose of this four week double blind study is to assess the efficacy of intermittent Theta-Burst Stimulation (iTBS)- rTMS in comparison to sham-rTMS (mimics the sensation and muscular discomfort of rTMS without stimulating the brain) in treating depressive symptoms.

ELIGIBILITY:

Individuals who meet all of the following criteria are eligible to participate in this trial:

  • Males and females aged between 18 to 70 years.
  • Have a diagnosis of Bipolar Type I Disorder with a current episode of depression.
  • Have failed to response to an adequate dose- or have been unable to tolerate the medication for treating Bipolar-1 depression.
  • Must be taking therapeutic levels of anti-manic agents (lithium or valproate) or any of atypical antipsychotics.
  • Pass the TMS adult safety screening (TASS) questionnaire.

    • Individuals meeting any of the following criteria are not eligible to participate in this trial:

  • Have unstable medical illnesses, including moderate to severe brain injury.
  • Have a personal or family history of
  • Have a diagnosis of any neurological disorders.
  • Have any other primary diagnosis of psychiatric or personality disorders (other than Bipolar-I)
  • Have failed a course of Electro Convulsive Therapy (ECT) for the current episode.
  • Are currently taking more than 3 of the atypical antipsychotics or lamotrigine alone.
  • Have a history of non-response to rTMS.
  • Have substance or alcohol abuse or dependence within the past 3 months.
  • Are at a significant risk of harm to themselves or others.
  • Are pregnant or lactating.

    • Remuneration: Participants will receive compensation for each clinic visit completed.
    This is to cover any incidental costs incurred during the study such as transportation and parking.

    Contact Information:

    For more information please contact:

    Sharon Ahn: (604)-822-7320

    E-mail: Sharon.ahn@ubc.ca