Non-Invasive Neurostimulation Therapies

Category: Journal Reviews

Preliminary results of rTMS study in depression at NINET Lab in Vancouver

The Temerty Centre for Therapeutic Brain Intervention  at CAMH, the rTMS Clinic  at Toronto Western Hospital and the NINET Lab at UBC/Centre for Brain Health presented preliminary results at the 1st International Conference in Singapore (work published in abstract form: Blumberger et al. Brain Stimulation 8 (2015) 326e342 -available on Researchgate.net).

This study compares the conventional rTMS treatment that takes 40 minutes to deliver every day for six weeks to a new from of TMS called Theta Burst Stimulation, which has been shown to induce synaptic plasticity more efficiently and only takes 3 minutes to deliver.

Based on a planned interim analysis of data comprising 105 participants with Treatment Resistant Depression, results showed that both groups  had a similar mean decrease in their depression symptoms of  37.1% (24.3 to 15.0) vs. 37.2% (24.1 to 14.8). There were no tolerability differences between groups. Groups did not differ on either dichotomous out-comes (response/remission rates 42.0%/20.0% vs. 40.7%/18.5%)

Preliminary Resuls


(note in the graph groups are referred as “A” and “B” as we are still blinded to treatment condition until the study is completed)

We are all very excited to see that the outcomes for both groups are in keeping with current efficacy rates of rTMS, and that there are no differences between groups so far. If this is the case at the conclusion of the study the implications will be far reaching translating into clinical practice rapidly and increasing access to rTMS to more patients.

-The NINET Lab

NINET Lab new research (Open Access): Mortality in marginally housed individuals

The NINET lab collaborated in this work published in the British Medical Journal Open Access edition. This paper shows a significant increase in standardized mortality ratio amongst in marginally housed individuals. This increase is as high as 8.29 Odds ratio. In other words, individuals in marginally housing situation has 8.29 more risk of dying adjusted by age and sex. Furthermore, psychosis and hepatic fibrosis (a condition of the liver caused mainly by chronic viral infections in our sample) were the two risk factors associated with this increase mortality. Both psychosis and hepatic fibrosis are treatable medical conditions.

Interested in learning more? check out the full paper here: Jones et al._Mortality from treatable illnesses in marginally housed adults a prospective cohort study._BMJ open_2015

Introduction to Journal Review


The NINET Lab would like to announce and introduce a new section to the website – The Journal Review. Dedicated to assessing various papers that the NINET Lab has discussed, The Journal Review will provide new users with the best opportunity at understanding the scientific field of Non-Invasive Neurostimulation.

The goal for this section is to not only provide the public with an insight into the world of Neurostimulation but to interpret scientific papers and make them more understandable and accessible to the general public.

So please, read on and look forward to more journal review posts in the future.

-The NINET Lab

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